It's going to have to be a very accurate platform to start with for the creedmoor to make sense IMO. But the hordes of people in the states with creedmoor AR10's show that it will reliably feed.
I've shot a small pile of rounds out of mine, hard use and competition. I've had absolutely ZERO hiccups so far, the rifle has run 100% flawlessly. Every. Single. Bit. As well as my friends DD....except my NEA is more accurate!! :p :p :p
More guns are hurt by cleaning them than by shooting them. That being said I like to keep my glocks maintained, but not spotless. Just don't let it "grunge" up. If it's your first handgun it may be hard to tell when the accuracy falls off.
I usually strip and clean mine everytime, I just don't...